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MAP KINASE SIGNALING SYSTEM
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DeCS
Descriptor
English
:
MAP Kinase Signaling System
Descriptor
Spanish
:
Sistema de Señalización de Quinasas PAM
Descriptor
Portuguese
:
Sistema de Sinalização das MAP Quinases
Synonyms
English
:
MAP Kinase Cascade
MAP Kinase Signaling Pathways
Tree Number:
G02.111.087.800.560
G02.149.115.800.560
G03.495.553.560
G04.299.880.560
Definition
English
:
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade,
MAP KINASE KINASE KINASES
; (MAPKKKs). Activated MAPKKKs phosphorylate
MITOGEN-ACTIVATED PROTEIN KINASE KINASES
which in turn phosphorylate the
MITOGEN-ACTIVATED PROTEIN KINASES
; (MAPKs). The MAPKs then act on various downstream targets to
affect
gene expression
. In
mammals
, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
See Related
English
:
MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
History Note
English
:
2000
Allowable Qualifiers
English
:
DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
34468
Unique Identifier:
D020935
Occurrence in VHL
:
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